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If you have any questions about your dosing, please reach out to your clinician

In some instances, the drug concentration for saturation the second receptor is about the same as the C min

As it is known that transactivation of Met can occur via epidermal growth factor (EGF)-dependent EGF receptor (EGFR) activation or through a constitutively activated EGFR pathway 20 , we examined whether inhibition of EGF-induced phosphorylation of EGFR by the dimeric macrocycles caused the bell-shaped response mentioned above